2022 United States Senate election in Alaska (LandonExists)

The 2022 United States Senate election in Alaska was held on November 8, 2022, to elect a member of the United States Senate to represent the State of Alaska, concurrently with the gubernatorial election, U.S. house election and other state and local elections.

Incumbent three-term Republican U.S. Senator Lisa Murkowski won re-election to a fourth term. Due to her opposition to some of his initiatives and her vote for his impeachment during his second trial, former U.S. President Donald Trump had pledged to campaign against Murkowski, implicitly endorsing a primary challenge in the process. However, due to the nature of Alaska's election process in the 2022 race, there was no formal Republican primary. Even if there was, Murkowski has survived a primary defeat before in 2010 as one of only two senators in history to have done so.

Following voter approval of Ballot Measure 2 during the 2020 elections in Alaska, this was the first U.S. Senate election in Alaska held under the new election process. All candidates ran in an all-party, open primary, from which the top four candidates advanced to the general election. Voters then utilized ranked-choice voting during the general election.

On March 16, 2021, the Alaska Republican Party voted to censure Murkowski, and formally announced that they would recruit a primary challenge to her, and prevent her as running as a Republican "to the extent legally permissible". However, partisan primaries were abolished by Ballot Measure 2, significantly reducing their chances of a successful primary challenge (in a partisan primary, only members of the party can participate), and the party could not prohibit her from associating as a Republican.

Advanced to general

 * Lisa Murkowski, incumbent U.S. Senator (2002-present)
 * Kelly Tshibaka, former commissioner of the Alaska Department of Administration

Eliminated in primary

 * Bob Lochner, mechanic and candidate for U.S. Senate in 2016

Declined

 * Mike Dunleavy, Governor of Alaska (2018–present) (running for re-election)
 * Laura Ingraham, author and Fox News host
 * Joe Miller, former U.S. magistrate judge, nominee for U.S. Senate in 2010, candidate for U.S. Senate in 2014, and Libertarian nominee for U.S. Senate in 2016
 * Sarah Palin, former Governor of Alaska (2006–2009) and nominee for Vice President of the United States in 2008

Eliminated in primary

 * Edgar Blatchford, member of the Anchorage school board (2021-present), professor at the University of Alaska Anchorage, former mayor of Seward, former chief editor of Alaska Newspapers, Inc., former commissioner of the Alaska Department of Community and Regional Affairs and the Alaska Department of Commerce, Community and Economic Development and candidate for U.S. Senate in 2016 and 2020

Advanced to general

 * John Howe, machinist and nominee for U.S. Senate in 2020

Advanced to general

 * Al Gross, orthopedic surgeon, commercial fisherman, son of former Alaska Attorney General Avrum Gross, and candidate for U.S. Senate in 2020